解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::A derivative UV spectrophotometric and a reversed phase high-performance liquid chromatographic method for the determination of ciprofibrate in tablets was developed. The first-order derivative UV spectrophotometric method was found to be accurate with 100.57±0.97 recovery and precise with a coefficient of variation o...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.103855
更新日期:2012-03-01 00:00:00
abstract::A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and validated for the estimation of tenoxicam in the microemulsion gels. Tenoxicam was chromatographed on silica gel 60 F(254) TLC plate, as a stationary phase. The mobile phase was toluene: ethyl acetate: formi...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.102541
更新日期:2012-01-01 00:00:00
abstract::A simple, accurate and sensitive spectroscopic method has been proposed for the assay of ciprofloxacin in tablet by least square treatment of fourier transform infrared spectrometric data obtained at the wavenumber corresponding to the carbonyl group centered at 1707 cm(-1). The method involves the extraction of the a...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.102551
更新日期:2012-01-01 00:00:00
abstract::Etoposide is a semisynthetic compound, widely used in treatment of non small cell lung cancer. However, frequent dosing and adverse effects remain a major concern in the use of etoposide. Liposomal systems for pulmonary drug delivery have been particularly attractive because of their compatibility with lung surfactant...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.100240
更新日期:2011-11-01 00:00:00
abstract::Fast dissolving tablets of clonazepam were prepared by sublimation method with a view to enhance patient compliance. A 3(2) full factorial design was applied to investigate the combined effect of two formulation variables: amount of croscarmellose sodium and camphor. Croscarmellose sodium (2-8% w/w) was used as superd...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.98984
更新日期:2011-09-01 00:00:00
abstract::A simple HPLC method was developed and validated for the quantification of zanamivir in permeability studies using Caco-2 cell culture model. Chromatographic resolution was achieved using 98% (v/v) ultrapure water and 2% (v/v) acetonitrile as mobile phase with flow rate of 0.5 ml/min on a BDS Hypersil Cyano column (le...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.99015
更新日期:2011-09-01 00:00:00
abstract::The effectiveness of liposome-mediated gene transfer methods hinges, in part, on the nature of the interaction between the DNA cargo and the liposomes. Here we have examined the effect of quaternization of the cytofectin cationic head group on this interaction and the effect of concentration of the biocompatible, prot...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.95613
更新日期:2011-07-01 00:00:00
abstract::A simple, precise, and accurate isocratic reversed-phase (RP) stability-indicating HPLC assay method was developed and validated for determination of Aripiprazole in bulk and solid pharmaceutical dosage form. A reversed-phase C8 (250×4.0 mm, 5 μm particle size) column for HPLC and C8 (50×2.1mm, 1.7 μm particle size) f...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.95638
更新日期:2011-07-01 00:00:00
abstract::Various (4-substituted) phenyl-3-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]propionylamido-1,3-thiazolidine-4-ones (3a-x) and 1-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]-propionylamido-3-chloro-4-(4-substituted)phenyl-azetidin-2-ones (4a-x) have been synthesised by the cyclocondensation of ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.95654
更新日期:2011-07-01 00:00:00
abstract::In order to increase the dissolution rate and bioavailability, solid dispersions of evodiamine in PVP K(30) with different enriched samples of evodiamine to PVP K(30) ratios were prepared by solvent method. Our studies showed that the dissolution rate of evodiamine was significantly higher in the solid dispersion syst...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.93511
更新日期:2011-05-01 00:00:00
abstract::A simple, sensitive and reproducible method was developed and validated for the simultaneous estimation of diethylcarbamazine and levocetirizine in its tablet formulation by reverse phase high performance liquid chromatography using Waters1515 HPLC with UV detector at the λ(max) of 224 nm, using Princeton Sphere-100 C...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.93517
更新日期:2011-05-01 00:00:00
abstract::In this paper we report the synthesis of a new family of 4-alkyl isocoumarin derivatives having bromo carbonyl and amino carbonyl group at 3(rd) position of the heterocyclic ring. Synthesis, spectral analysis and bioactivity of new isocoumarin derivatives are discussed in this paper. Some of the synthesized compounds ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474x.91586
更新日期:2011-03-01 00:00:00
abstract::Two triterpenoids, taraxerone and tricadenic acid A were isolated from the methanol extract of the outer bark of Schleichera oleosa available in Darjeeling foothills. A preliminary study on their antimicrobial activities was also performed against some fungal and bacterial species. The structure of these compounds was...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474x.91568
更新日期:2011-03-01 00:00:00
abstract::Malnutrition is widely prevalent among patients on hemodialysis. Malnutrition can be estimated using a fully quantitative scoring system Subjective Global Assessment-Dialysis Malnutrition Score which is simple, reliable and dynamic. The primary objective of the study was to assess the severity of malnutrition in patie...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.89755
更新日期:2011-01-01 00:00:00
abstract::An in vitro evaluation of the anti-microbial activity of medicated soaps was conducted using ditch-plate and hand washing techniques. Strains of reference microbes namely Candida albicans (ATCC90028), Staphylococcus aureus (ATCC25923), Pseudomonas aureginosa (ATCC27853) and Escherichia coli (ATCC25922) were tested at ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.89765
更新日期:2011-01-01 00:00:00
abstract::In the present study petroleum ether and alcoholic extracts of Centratherum anthelminticum (L) Kuntze seed (100 mg and 200 mg/kg p.o.) were evaluated for antiinflammatory activity in acute and subacute models of inflammation. It was found that both petroleum ether and alcoholic extracts showed significant reduction in...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.84577
更新日期:2010-11-01 00:00:00
abstract::Modification of polymers by covalent attachment of thiol bearing pendant groups is reported to impart many beneficial properties to them. Hence in the present study, sodium alginate-cysteine conjugate was synthesized by carbodiimide mediated coupling under varying reaction conditions and the derivatives characterized ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.84590
更新日期:2010-11-01 00:00:00
abstract::A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.84603
更新日期:2010-11-01 00:00:00
abstract::WHO reports estimate poisoning as one of the most common causes of increased morbidity and mortality rate world-wide. Various agents such as pesticides, drugs have been used for intentional and accidental poisoning in different countries. In the Indian scenario, pesticides are the most commonly used poisoning agents. ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.78525
更新日期:2010-09-01 00:00:00
abstract::Supercritical fluid extract of leaves of Vitex negundo was tested for its antimicrobial potential and was compared with that of ethanol extract, ether extract and hydrodistilled oil of leaves. The chemical constituents of extracts were studied by chromatographic techniques. Extracts were evaluated for antimicrobial po...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.78537
更新日期:2010-09-01 00:00:00
abstract::A novel reversed-phase HPLC method has been developed and validated for the simultaneous determination of 2-phenoxyethanol, methylparaben, ethylparaben and propylparaben preservatives. The method uses a Lichrosorb C8 (150×4.6 mm, 5 µm) column and isocratic elution. The mobile phase consisted of a mixture of acetonitri...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.73906
更新日期:2010-07-01 00:00:00
abstract::The genome of rabies virus encodes five proteins; the nucleoprotein, the phosphoprotein, the matrix protein, the glycoprotein, and the RNA-dependent RNA polymerase. Among these, the glycoprotein is the most important as it is the major contributor to pathogenicity and virus neutralizing antibody response. Keeping in m...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.73905
更新日期:2010-07-01 00:00:00
abstract::Antianthelmintic activity of successive extracts (chloroform, acetone, ethanol and aqueous) of Nauclea orientalis leaves were evaluated separately on adult Indian earthworm (Pheretima posthuma) and compared with that of albendazole. It was found that the extracts exhibited, respectively dose-dependent action and inhib...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.73932
更新日期:2010-07-01 00:00:00
abstract::Fexofenadine is a selective histamine H(1) receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.70477
更新日期:2010-05-01 00:00:00
abstract::In the present study, the effect of essential oil of the root of Angelica archangelica Linn. was evaluated against electrically and chemically induced seizures. The seizures were induced in mice by maximal electroshock and pentylenetetrazol. The effect of essential oil of the root of Angelica archangelica on seizures ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.70487
更新日期:2010-05-01 00:00:00
abstract::The aim of this research was to investigate the technique for preparation of coated valproic acid and sodium valproate sustained-release matrix tablets. Different diluents were tested and selected as the effective absorbent for oily valproic acid. Effect of the amount of absorbent and hydroxypropylmethylcellulose on d...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.65026
更新日期:2010-03-01 00:00:00
abstract::The present work describes a simple, precise and accurate HPLC method for estimation of montelukast sodium in bulk and in tablet dosage form. The separation was achieved by using octadecylsilane column (C18) and acetonitrile:1 mM sodium acetate adjusted to pH 6.3 with acetic acid in proportion of 90:10 v/v as mobile p...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.65023
更新日期:2010-03-01 00:00:00
abstract::The present study evaluated the in vitro antioxidant potential of different parts of Oroxylum indicum. 2,2-diphelyl 1-picrylhydrazyl (DPPH), nitric oxide, superoxide anion and hydroxyl radical scavenging potential and reductive ability assay of methanol extract of different parts i.e. root, root bark, stem, stem bark,...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.65013
更新日期:2010-03-01 00:00:00
abstract::Present study reports the development and validation of a simultaneous estimation of metformin and gliclazide in human plasma using supercritical fluid chromatography followed by tandem mass spectrometry. Acetonitrile:water (80:20) mixture was used as a mobile phase along with liquid CO(2) in supercritical fluid chrom...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.62231
更新日期:2010-01-01 00:00:00
abstract::A simultaneous determination of olmesartan medoxomil and hydrochlorothiazide by absorption ratio spectrophotometric method has been developed in combined tablet dosage form. The method is based on measurements of absorbance at isoabsoptive point. The Beer's law obeys in the range of 10-30 mug/ml for both olmesartan me...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.62245
更新日期:2010-01-01 00:00:00
abstract::Alpinia officinarum is a rhizome belonging to the family zingeberaeceae. Hydro alcoholic extract by hot and cold maceration and methanol extract by percolation process Qualitative phytochemical analysis of extract of Alpinia officinarum rhizome showed a majority of the compound including tannins, alkaloids, flavonoids...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.62233
更新日期:2010-01-01 00:00:00
abstract::Present study aims to prepare and evaluate niacin microspheres. Niacin-ethyl cellulose microspheres were prepared by water-in-oil-in-oil double emulsion solvent diffusion method. Spherical, free flowing microspheres having an entrapment efficiency of 72% were obtained. The effect of polymer-drug ratio, surfactant conc...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.59549
更新日期:2009-11-01 00:00:00
abstract::A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of escitalopram oxalate and clonazepam in combined dosage form. Simultaneous equation method is employed for simultaneous determination of escitalopram oxalate and clonazepam from combined dosage forms. In this meth...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.59559
更新日期:2009-11-01 00:00:00
abstract::A gradient reversed phase HPLC method was developed and validated for the analysis of related substances in zonisamide (1,2-benzisoxazole-3-methanesulfonamide), using a Waters Symmetry C8 (150*3.9 mm) column with a flow rate of 1.0 ml/min and detection at 280 nm. The mobile phase component A consisted of a mixture of ...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.58183
更新日期:2009-09-01 00:00:00
abstract::Two UV Spectrophotometric and one reverse phase high performance liquid chromatography methods have been developed for the simultaneous estimation of amlodipine besilate and olmesartan medoxomil in tablet dosage form. First UV spectrophotometric method was a determination using the simultaneous equation method at 237....
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.58190
更新日期:2009-09-01 00:00:00
abstract::Crystal form can be crucial to the performance of a dosage form. This is especially true for compounds that have intrinsic barriers to drug delivery, such as low aqueous solubility, slow dissolution in gastrointestinal media, low permeability and first-pass metabolism. The nature of the physical form and formulation t...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.57283
更新日期:2009-07-01 00:00:00
abstract::A series of novel N-Sulphonamidomethyl piperzinyl fluoroquinolones were synthesized and screened antiviral activity. Eight compounds were synthesized through modifying the N(4)-hydrogen of piperazine in fluoroquinolones with formaldehyde and sulphanomides by Mannich reactions. The structures of the synthesized compoun...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.57293
更新日期:2009-07-01 00:00:00
abstract::Mebeverine hydrochloride is known to suffer from extensive first pass effect. In an attempt to improve its oral bioavailability and possibility to restrict its absorption only to the colon, mebeverine microspheres were prepared by emulsion solvent evaporation method. Four formulations were prepared with varying drug a...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.57303
更新日期:2009-07-01 00:00:00
abstract::The aim of the present study was the determination of formulation factors and the in vitro evaluation of an extended release dosage form of a freely soluble weakly basic drug (alfuzosin hydrochloride). Binary mixer of one hydrophilic polymer (hydroxypropylmethylcellulose) and one directly compressible Eudragit (RS PO)...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.56019
更新日期:2009-05-01 00:00:00
abstract::Ethanol extract of Passiflora edulis Sims was analyzed for its antioxidant (1,1-diphenyl-2-picryl hydrazyl radical reducing power methods) and phytochemical analysis. The extract was found effective against the antioxidant test models exhibiting an IC(50) value of 875+/-87.83 mug/ml and showed strong potential antioxi...
journal_title:Indian journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.4103/0250-474X.56038
更新日期:2009-05-01 00:00:00